Abstract
The transfer of immunocompetent lymphoid cells from inbred guinea pigs to allogeneic recipients that had been primed with DNP-ovalbumin prepared such recipients for striking secondary anti-DNP antibody responses to an appropriately timed challenge with DNP-bovine γ globulin. This phenomenon (“allogeneic effect”) involved activation of host antibody-forming cell precursors (ACFP) as a result of the specific immunologic attack of donor cells. Thus, parental (strain 2) donor lymphoid cells elicited this phenomenon in (2 × 13)F1 recipients, whereas, as shown previously, F1 donor cells failed to elicit the response in parental recipients. The allogeneic effect can be elicited in recipients primed as early as 1 day or as long as 130 days prior to allogeneic cell transfer, although the effect was maximal at 21 days. Furthermore, the allogeneic effect appeared to cause expansion of the AFCP population of the recipient as well as differentiation of such cells into antibody-secreting cells.
