An antigen in tissue from mink infected with Aleutian disease, detectable by agar-gel electrophoresis, was partially purified by fluorocarbon treatment and concentration by ultracentrifugation from the spleen, kidney and liver of experimentally infected mink. Antibody against this antigen, which seems to be specific for AD, appeared as early as 9 days after experimental infection. Normal animals had no detectable antigen or antibody specific for AD virus.

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This work was supported by Grant MA 2001 from the Medical Research Council of Canada.

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