Genetic Regulation of the Thymus Dependent Humoral Immune Response in Leukemia Prone Akr (H-2^k) and Nonleukemic C3H (H-2^k) Mice: Description of Genetic Control of the Immune Response at the Level of Proliferation

Defective immunopoiesis in young adult AKR mice has been shown to be genetically regulated. Transfer of identical numbers of cells from the same spleen cell suspension into x-irradiated young adult mice of the AKR and C3H strains, the F₁ and F₂ progeny of these two strains, and the progeny of the two F₁ backcrosses has provided direct evidence that the regulation of immunocompetent cell proliferation is genetic in nature. Statistical tests indicate that the evidence for genetic differences is consistent with a single, apparently non-H-2, autosomal gene locus.