Allergic histamine release from rabbit platelets can be initiated through the alternate pathway of C activation. The release reaction proceeds in the absence of the Fc portion of the antibody molecule. The time course of release due to this pathway is slower than that after activation of the classical C sequence. Platelet injury due to immune complexes through both pathways requires the sixth C component.

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Support for this investigation was received, in part, from the National Science Foundation, Grant GB-31738X; the American Cancer Society, Inc., Grant T-257 and the National Institute of Allergy and Infectious Diseases of the United States Public Health Service, Grants AI-08710 and AI-10455.

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