Neonatal thymectomy of Obese strain chickens significantly increased the severity of spontaneous autoimmune thyroiditis, assessed by histologic study at the end of 4 weeks. The effect is not due to surgical trauma to the thyroid gland. A balance between bursal function (which promotes the autoimmune disorder) and thymic function (which suppresses it) is thus apparent.


This work was supported by Research Grant CA-02357 from the National Cancer Institute and by Training Grant AI-00130 from National Institute of Allergy and Infectious Diseases. This is publication No. 49 from The Center for Immunology.

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