Evidence is presented that T cell impairment appears to be specifically related to the pathogenesis of experimental amyloidosis. This conclusion is based on the finding that thymosin administration improves T cell function as measured by mitogen stimulation of spleen cell suspension and at the same time reduces the incidence and severity of amyloid disease in casein-treated mice.

1

These investigations were supported by grants from the United States Public Health Service. National Institute of Arthritis and Metabolic Diseases (AM-04599 and Tl-AM-5285), from the General Clinical Research Centers Branch of the Division of Research Resources, National Institutes of Health (RR-533), from the Massachusetts Chapter of the Arthritis Foundation, from the Arthritis Foundation, from the John A. Hartford Foundation and from the National Cancer Institute (Ca 14108 and Ca 15419).

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Copyright © 1976 by The American Association of Immunologists, Inc.
1976
The Williams & Wilkins Company