Abstract
The induction of specific immunologic tolerance and its transfer has been studied in the in vitro response of unprimed rabbit spleen cells to solubilized phage antigens. Evidence presented shows that only viable cells transfer tolerance and that the responsible cells appear devoid of membrane-bound antigen but are sensitive to anti-thymocyte serum. It appears, therefore, that although the in vitro response to solubilized S-T2 has no demonstrable requirement for T “helper” cells, it is subject to the action of T “suppressor” cells.
Footnotes
This work was supported by Training Grant AI-00408, and Grants AI13180-01 and AI13159-01 from the National Institutes of Health.
A preliminary report on these studies was presented at the Annual Meeting of the Federation of American Societies for Experimental Biology, April, 1975.
