A radioimmunoassay for thymopoietin was developed that detects thymopoietin concentrations greater than 5 ng/ml. A critical point in development of the radioimmunoassay was preparation of 125I-labeled thymopoietin by the Bolton-Hunter method, since direct iodination of tyrosyl residues impaired the immunoreactivity of thymopoietin.

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This work was supported by United States Public Health Service Grants CA-08748, AI-12487, CA-17085 and Contract CB-53868 from the National Cancer Institute.

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Copyright © 1976 by The American Association of Immunologists, Inc.
1976
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