In “Purification and Characterization of a Liver-Specific Antigen” by Anastasios A. Mihas, Basil I. Hirschowitz, and Gaetano Saccomani in the May issue of the Journal of Immunology, Volume 116, Number 5, page 1228, the introduction was omitted by the printer and is reproduced below.

Evidence for the existence of an antigen with organ specificity for liver has been presented previously (1). In these studies, certain strains of mice when immunized with liver extracts from other strains of mice produced precipitating autoantibody against an antigen present in the liver of all mice. This antigen (F-antigen) was also found in liver extracts from several mammals. Recently, the F-antigen, was demonstrated in the serum of several patients with liver disease and it was speculated that it may be an important index of hepato-cellular destruction (2–4), although its biologic significance remains poorly understood. So far, no reports of isolation of the F-antigen have been published and its immunologic and physicochemical properties are not known.

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