Mouse spleen cells treated with glutaraldehyde lose their stimulating ability in the MLR. If the spleen cells are first converted to a blastogenic state by lipopolysaccharide and subsequently fixed with glutaraldehyde, their stimulating capacity is maintained.

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This work was supported by National Institutes of Health Grants AI 11923 and AI 11013, and by the Michigan Heart Association and Kidney Foundation of Michigan.

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