When trypsinized cells were treated with alloantibody and complement they initially adhered to their substratum, then detached. Specific cytolysis did not occur. In addition to demonstrating an immunologically mediated reaction, this phenomenon has permitted the development of a new, simple, rapid assay for alloantibody that does not require a cytolytic reaction.

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This work was supported by United States Public Health Service. This is publication Number 1256 from the Department of Molecular Immunology, Scripps Clinic and Research Foundation Grant CA 15586.

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