We have shown that administration of anti-C5 antibody to newborn mice heterozygous for C5 deficiency can suppress C5 levels for prolonged periods. This is analogous to antibody-induced immunoglobulin allotype and idiotype suppression. Only certain sources of anti-C5 are effective in suppression. Of the three antisera extensively tested in (SWR × RIII)F1 hybrids, A/He anti-RIII was the most effective, SWR anti-RIII was less effective, and SWR anti-DBA/1 was ineffective. Only certain strain combinations of F1 hybrids are susceptible to C5 suppression. C5 suppression was seen with (SWR × RIII)F1 hybrids but not (SWR × DBA/1)F1 hybrids. Kinetics of C5 suppression suggest a requirement for an active, ongoing process in the maintenance of low C5 levels.

1

This work was supported by the Medical Research Institute Council, Michael Reese Hospital and Medical Center, Research Grant AI 12792 from the National Institutes of Health, and a research grant from the Leukemia Research Foundation, Inc., Chicago, Illinois.

2

Presented in part at the annual meeting of the Federated Societies for Experimental Biology, April 1977 (Fed. Proc. 36:1250).

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