The effects of anti-Qa-2 plus C and anti-Qa-3 plus C on mitogen-induced proliferation were studied. Both of these antisera in the presence of C markedly reduced both Con A- and PHA-induced proliferation while having little or no effect on LPS-induced proliferation. LPS, Con A, and PHA cultures and cultures containing media alone, examined at 72 hr, contained high proportions of Qa-2+ and Qa-3+ cells.

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This work was supported in part by National Institutes of Health Grant AI 12603 awarded by the National Institute for Allergy and Infectious Diseases, Bethesda, Maryland.

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