The amino terminal sequence of seven newly studied and three previously reported γ Heavy Chain disease proteins show that they begin at several sites ranging from position 215–234 in the hinge region. The presence of more than one species of molecule in several of the sera and the susceptibility of this region to proteolytic cleavage, taken together with the finding of a blocked Heavy Chain disease protein in the serum of one and the cells of another patient support the concept that these molecules are the result of proteolytic cleavage of typical Heavy Chain disease proteins.

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This work was supported by United States Public Health Service Research Grants AM 01431 and AM 02594, The Irvington House Institute, and The Helen and Michael Schaffer Fund.

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