Roderich E. Schwarz and John C. Hiserodt. The Expression and Functional Involvement of Laminin-Like Molecules in Non-MHC Restricted Cytotoxicity by Human Leu-19+/CD3 Natural Killer Lymphocytes. The Journal of Immunology, 1988, 141: 3318–3323 .

The Journal received the following letter from Roderich E. Schwarz requesting correction of this article, which was published in the November 15, 1988 issue:

To the editor:

This is a formal request for a correction to a paper which appeared in The Journal of Immunology in November 1988 (R. E. Schwarz and J. C. Hiserodt), in response to a recommendation by the Office of Research Integrity (ORI) of the Public Health Service, Department of Health and Human Services. In 1994, the ORI had performed an investigation against the senior author of the manuscript titled “The expression and functional involvement of laminin-like molecules in non-MHC restricted cytotoxicity by human Leu-19+/CD3 natural killer lymphocytes,” the summary of which has been tagged to the PubMed reference of this article (http://grants1.nih.gov/grants/guide/notice-files/not94-105.html). In this ORI report, a requirement to correct the journal article, namely the indication that Fig. 2 of the article cannot be relied upon, was issued. Such recommendation remains sensible today, albeit 16 years after the original publication, as the investigation apparently failed to identify documented experimental data upon which the figure had been generated, and is hereby formally requested. However, the general ability to inhibit human adherent lymphokine-activated killer (A-LAK) cell cytotoxicity by F(ab′)2 of anti-laminin Ab, as stated in the legend of Fig. 2, should not be questioned. A figure, which is based on actual experimental data and reflects the inhibitory effect, is therefore added to this correction request, to replace the original Fig. 2.

FIGURE 2.

Inhibition of cytotoxicity by two different human A-LAK cell populations through F(ab′)2 of affinity-purified anti-laminin Ab. Sorted Leu-19+/CD3 and Leu-19+/CD3+ A-LAK cell populations were mixed with Cr-labeled target cells in the continued presence of 150 μg/ml Ab for 4 h, and the resulting lytic activity was calculated as specified in Materials and Methods.

FIGURE 2.

Inhibition of cytotoxicity by two different human A-LAK cell populations through F(ab′)2 of affinity-purified anti-laminin Ab. Sorted Leu-19+/CD3 and Leu-19+/CD3+ A-LAK cell populations were mixed with Cr-labeled target cells in the continued presence of 150 μg/ml Ab for 4 h, and the resulting lytic activity was calculated as specified in Materials and Methods.

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