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In regards to Ref. 54 (Iyer, S. S., W. P. Pulskens, J. J. Sadler, L. M. Butter, G. J. Teske, T. K. Ulland, S. C. Eisenbarth, S. Florquin, R. A. Flavell, J. C. Leemans, and F. S. Sutterwala. 2009. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc. Natl. Acad. Sci. USA 106: 20388–20393), an error occurred in the Discussion section on p. 6282 of the article, which states that “The mice used in the study were backcrossed onto C57BL/6 mice for only four generations…”. This was a mistake; the mice used in Ref. 54 were backcrossed for nine generations. We apologize for this error and regret any inconvenience.