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Following an inquiry at Duke University, we were informed that FlexiVent data provided to us by the animal pulmonary physiology laboratory at Duke University may have been unreliable. We therefore repeated the experiments described in Fig. 1 of the published article and were unable to replicate the airway hyperresponsiveness findings. Therefore, we have concerns about the integrity of the data published in Fig. 1. We hereby retract Fig. 1 and its legend from the published article. The other data presented in the article are not affected by the unreliable FlexiVent data, and retraction of the FlexiVent data described in Fig. 1 does not impact the overall conclusions of the published article.
Retraction of Fig. 1 means that the following changes need to be made to the text of the published article:
In the fourth sentence of the Abstract, the words “enhanced airway hyperreactivity” need to be omitted.
The first section of the Results, entitled Ozone enhances airway hyperresponsiveness in response to inhaled LPS, should be removed.
In the Discussion section, the following text should be removed: “airway hyperreactivity” in the second sentence; “in TLR4-dependent AHR, this study further supports the dichotomy between cellular inflammation and AHR” in the second to last sentence of the fifth paragraph; and “of airway hyperresponsiveness” in the last sentence of the fifth paragraph.
