In order to throw light on the question of the origin of “anaphylatoxin,” Doerr and Pick (Centralbl., 62, Orig., p 146) and Römer and Viereck (Zeitschrift f. Immunitätsforsch., Orig., Bd. xxi, p. 32) measured the disappeaance of antibodies in heterologous sera in anaphylactic animals.

Doerr and Pick injected a rabbit sensitized to horse serum and a normal rabbit intravenously with cholera agglutinating horse serum, and they found that the amount of agglutinin and of the precipitable horse albumen remained the same in both for about a day and then disappeared faster from the anaphylactic animal than from the other. They injected guinea pigs sensitized to horse serum intraperitoneally with 1 to 2 cc. of cholera agglutinin from the horse and found that the agglutinin and the precipitable horse albumen appeared in the circulation of the sensitized animals more quickly than in that of the others and, up to six hours after injection, they were present in greater quantity.

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