Analyses of the anaphylactic and immune reactions by means of perfusion experiments with the isolated guinea-pig lungs show that we are here concerned with three essential factors:

  • Cellular hypersensitiveness, or the anaphylactic response of the hypersensitive fixed pulmonary tissues,

  • Humoral anaphylaxis, or the chemical response (anaphylotoxin formation) of the anaphylactic blood, and

  • Humoral immunity, or the inhibiting or protecting action of the immune blood.

In the 14-day anaphylactic guinea-pig, the fatal bronchial spasm is due, in part to fixed cellular hypersensitiveness, in part to humoral anaphylaxis.

In the 4-week anaphylactic guinea-pig, the fixed cellular hypersensitiveness is usually greater than that of the 14-day anaphylactic guinea-pig. The humoral reaction, however, is usually absent. The fatal bronchial spasm in the 4-week anaphylactic guinea-pig is usually due solely to fixed cellular hypersensitiveness.

The immune guinea-pig usually shows a fixed cellular hypersensitiveness greater than that of the 14-day anaphylactic guinea pig. A fatal bronchial spasm is prevented in the immune guinea-pig, however, by the inhibiting or protecting action of the immune blood.

The immune guinea-pig, therefore, shows a seemingly paradoxical phenomenon, the coexistence of a fixed cellular hypersensitiveness and a humoral immunity.


Presented before the Society of American Bacteriologists, New Haven, Conn., December 27, 1916, and before the American Society for Experimental Pathology, New York City, December 28, 1916.

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