Before discussing the results of immunologic studies made in typhus exanthematicus, the relationship of the B. typhi-exanthematici to this disease will be briefly stated.

Up to the present time, this organism has been recovered from the blood of patients suffering from typhus fever endemic or epidemic in the various parts of the world—the United States, Serbia, Bulgaria, Russia and Mexico. It has also been recovered from the blood and spleen of animals, guinea-pigs and monkeys, injected with infectious typhus-fever blood. It has been isolated from typhus-infected lice. It has not been recovered from numerous nontyphus patients, nor from tissues of normal animals, nor from “normal” (nontyphus) lice.

In regard to positive blood cultures in human and experimental typhus fever in animals, the organism can be recovered during the entire febrile period of the disease. It is also found in greatest numbers during the early stages of the disease, especially the chill, and more often in severe than in mild cases.

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Work done under the tenure of the Eugene Meyer, Jr., and a George Blumenthal, Jr., Fellowships in Pathology.

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