The experimental foundation for a non-specific vaccine therapy was laid by Emmerich (1) thirty years ago. He showed that rabbits inoculated with streptococci possessed a certain amount of immunity against anthrax. He also observed that an anthrax infection in rabbits, even after it had called forth distinct symptoms, could be favorably influenced by the injection of streptococci—particularly if the latter injection was administered intravenously. Pawlovsky (2) confirmed these results, and demonstrated that Friedländer's bacillus and B. prodigiosus also retarded the development of the anthrax infection. Bouchard (3) found that B. pyocyaneus could be used for this purpose. Then Freudenreich (4) and Woodhead and Cartwright Wood (5) obtained similar results with killed cultures of B. pyocyaneus, and Buchner (6), with killed cultures of Friedländer's bacillus. Von Dungern (7) injected killed cultures of Friedländer's bacillus intravenously and observed that rabbits so treated were more resistant to anthrax bacilli inoculated subcutaneously one or several days later, than were normal rabbits.

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