Bou Ghanem, E. N., N. H. T. Maung, N. Siwapornchai, A. E. Goodwin, S. Clark, E. J. Muñoz-Elías, A. Camilli, R. M. Gerstein, and J. M. Leong. 2018. Nasopharyngeal exposure to Streptococcus pneumoniae induces extended age-dependent protection against pulmonary infection mediated by antibodies and CD138+ cells. J. Immunol. 200: 3739–3751.

The first panel of Fig. 7A was inadvertently duplicated in the published article. Fig. 7A should appear as shown below. The figure has been revised so that the correct right panel has been added. The figure legend was correct as published and is shown below for reference.

FIGURE 7.

Abs elicited by i.n. exposure confer extended protection against i.t. challenge. (A) At 10 and 18 wk after NP exposure of 8-wk-old C57BL/6 mice to S. pneumoniae TIGR4, IgG (left panel) and IgA (right panel) Abs against indicated Ags were measured in sera. Each point represents an individual mouse, and dotted lines indicate the limit of detection. (B) Ten weeks and (C) 20 wk after NP exposure, NP-exposed (○) or naive mice (▲) were i.t. challenged with 2 × 106 CFU of S. pneumoniae TIGR4 and survival was assessed at indicated times after i.t. challenge. Fractions denote survivors 2 wk after challenge over the total number of mice. The log-rank (Mantel–Cox) test was used to calculate p values. Asterisks indicate p < 0.05.

FIGURE 7.

Abs elicited by i.n. exposure confer extended protection against i.t. challenge. (A) At 10 and 18 wk after NP exposure of 8-wk-old C57BL/6 mice to S. pneumoniae TIGR4, IgG (left panel) and IgA (right panel) Abs against indicated Ags were measured in sera. Each point represents an individual mouse, and dotted lines indicate the limit of detection. (B) Ten weeks and (C) 20 wk after NP exposure, NP-exposed (○) or naive mice (▲) were i.t. challenged with 2 × 106 CFU of S. pneumoniae TIGR4 and survival was assessed at indicated times after i.t. challenge. Fractions denote survivors 2 wk after challenge over the total number of mice. The log-rank (Mantel–Cox) test was used to calculate p values. Asterisks indicate p < 0.05.

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