Summary
Of 53 rabbits treated with the Grove series of injections with egg white (described in the text), 70 per cent were made maximally sensitive to intravenous test, 5.6 per cent exhibited slight symptoms of anaphylaxis and 24.4 per cent failed to show any symptoms. Similar results were obtained with horse serum.
Variations in the number or the selected routes of the injections lessened the effectiveness of the treatment in establishing anaphylactic sensitiveness in the animals.
The established sensitiveness persists for at least two or three weeks.
An additional subcutaneous injection given one week after the period of highest sensitiveness usually causes no diminution in the concentration of the blood-borne antibodies; nevertheless the sensitiveness of the animals is always greatly diminished or entirely extinguished.
Active sensitization of rabbits does not depend entirely upon the degree of antibody productivity because animals showing a high power of antibody production may be wholly insensitive and vice versa.
Footnotes
The work reported in this series of papers was carried out in part in the Robert Koch Institute, Berlin under the tenure of the first scholarship of the Gardiner School Alumnae Association of New York City.
