In previous articles concerning serum sickness in rabbits we have reported some of the manifestations of this reaction (1) and certain phenomena associated with this reaction such as appearance of antibodies (2), alterations in temperature and white blood cells (3). The results here reported are based upon experiments carried out to determine some of the factors concerned in the occurrence of serum sickness in rabbits. As concerns the appearance of this phenomenon in man there have appeared in the literature statements that serum from various horses differed in their activity in causing serum sickness, that age of the serum might be of moment and that the individual variation of the person injected played a rôle. Very little has been stated regarding the effect of serum from species other than horse in causing this reaction. Our studies were undertaken to throw some light upon these questions in their relation to manifestations in the rabbit.

1

This work was aided by a grant (no. 170) from the Therapeutic Research Committee of the American Medical Association.

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