The growth and migration of cells in explants from the spleen and bone marrow of tuberculous guinea pigs are inhibited by the addition of tuberculin; those explanted from non-tuberculous guinea pigs sensitized by a single injection of horse serum are not inhibited by horse serum.
Migration and growth in similar explants from tuberculous guinea pigs sensitized to horse serum are not inhibited by the addition of horse serum; it was found that they are, on the other hand, inhibited by tuberculin.
When the Arthus phenomenon was elicited by injections of horse serum into normal and tuberculous guinea pigs the tissue cultures were unaffected by the addition of the serum.
These tissue-culture experiments suggest that the mechanism underlying the tuberculin reaction is different from the mechanisms of anaphylaxis and the Arthus phenomenon.
Read April 27, 1932 at the nineteenth annual meeting of The American Association of Immunologists.