We have been unable to obtain evidence of attenuation of the poliomyelitis virus by 1 per cent sodium ricinoleate.3

Thirty animals received 5 doses each by subcutaneous inoculation at weekly intervals. Sixteen of the animals developed sufficient neutralizing substance in their blood to neutralize a single constant infective dose of virus. All but 2 succumbed to the intracerebral inoculation of the same dose of virus.


This work is supported by grants from the Rockefeller Foundation, the Friedsam Foundation, and by a grant from the President's Birthday Ball Commission for Infantile Paralysis Research.


In a personal communication Kolmer agreed with us that no appreciable attenuation occurred.

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