Variations in the concentrations of phospholipids and of free and esterified cholesterol in the plasma and serum of horses previous to and during immunization with diphtheric and tetanal toxins, and with meningococci, streptococci, and pneumococci are recorded.

The fluctuations in the different lipids during immunization were approximately proportional and their ratios fairly constant, except in certain horses with acute diphtheric toxemia.

The main trends in the process of immunization were a decrease in the lipid content during the early period followed by a return to the normal range. The depressions, however, varied in degree and were most marked with the exotoxins, practically absent in the horses injected with pneumococci.

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