Experiments on the guinea pig show that a relatively mild alarm reaction, followed by an interval of 18½ to 24 hours rest, decreases the anaphylactic response of sensitized guinea pigs to the subsequent reinjection with the antigen. This observation gives further support to the conception that the alarm reaction increases the non-specific resistance of the organism against various nocuous agents. If, on the other hand, the alarm reaction is particularly severe and the interval between the treatment with the alarming agent and the reinjection of the antigen is short, such pretreatment may have an inverse effect and may actually increase the severity of the anaphylactic shock.

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