An examination of the experimental evidence of the preceding pages would appear to have established the following facts:

  1. That B. influenzae is capable of producing a toxic substance.

  2. That this substance, when introduced into the circulation, produces congestion of the respiratory tract with haemorrhages into the alveoli.

  3. That certain conditions of symbiotic growth intensify the liberation of the toxin.

  4. That as an effect of the action of the poison the lungs show a predisposition to invasion by various organisms, with the production of secondary lesions.

  5. That live bacilli introduced at a remote point probably affect the lungs through the action of a liberated toxin.

  6. That there is nothing in the serological evidence to preclude the consideration of this organism as an important factor in the causation of clinical influenza.


Read before the New York Pathological Society March 12, 1919; before the Philadelphia Pathological Society March 27, 1919.

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