The question as to the site of the specific protein-antiprotein reaction that is the original cause of the symptoms of anaphylaxis may be considered settled beyond reasonable doubt. The final acceptance of the “cellular theory” of anaphylaxis has been forced by unequivocal evidence in the case of the guinea-pig as well as of the dog. A detailed analysis of this evidence is in press elsewhere (1).
One of the arguments supporting the cellular theory was gained with the use of the process of perfusion, the purpose of which was to show that a once established hypersensitiveness persists after the blood contained in the vessels has been displaced with normal blood or saline solution.
This research was supported by a fund contributed by the writer's friend, Major -- --, M.R.C., U. S. A.