There are numerous reports in the literature of reactions occurring in hypersensitive recipients after their transfusion with normal blood containing allergens. The development of similar reactions in normal recipients following their transfusion with reaginic blood has been recorded in a few instances. In 1919 Ramirez (1) first suggested this possibility when he described the occurrence of asthma in a man who had received a transfusion two weeks previously. The initial attack developed shortly after the recipient had entered a horse-drawn vehicle, and a second paroxysm came on the next morning while the patient was walking in a park. Both the recipient and the donor were subsequently found to possess cutaneous reactivity to horse dander, a situation which suggested strongly that the donor's susceptibility had been transferred to the recipient. Although a previous transfusion of 800 ml of blood from the same donor had not caused asthma in another recipient, no assurance was given that this recipient had been exposed to horse dander.
Presented at the Sixteenth Annual Meeting of the Society for the Study of Asthma and Allied Conditions at Atlantic City on May 4, 1940.