1. Staphylococci are of low virulence for mice and rabbits, and their infectivity is increased with great difficulty, if at all.

  2. With appropriate strains, the chick embryo is reasonably susceptible to infection.

  3. Localized infections may be induced with greater regularity in the skin and cornea of rabbits, so that protective tests are possible under the conditions stated.

  4. In spite of nonspecific protection present in normal and heterologous sera, specific protection can be demonstrated in antistaphylococcal Type A serum.

1

This study was started at Washington University School of Medicine, St. Louis, Mo., under a grant from the Commonwealth Fund.

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