1. In a series of complement-fixation tests with the antigen of lymphogranuloma venereum (lygranum) on 800 sera from 744 patients, four-plus fixation was obtained with 28.5 per cent of sera from individuals with known histories of venereal exposure, and with 8.5 per cent of sera from persons who were presumably not exposed.

  2. When Frei tests were done on patients whose sera gave complete fixation, about one-third were positive, giving reactions at least 6 mm in diameter.

  3. The significance of the complement-fixation reaction is discussed.

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