Inasmuch as the intravenous injection of persons with large amounts of immune horse serum as in the serum treatment of pneumonia, is sometimes followed by symptoms not referable to anaphylaxis, the purpose of this investigation was to study normal and immune horse sera for hemagglutinins and hemolysins for human erythrocytes to ascertain whether intravascular agglutination or hemolysis are responsible in part for these symptoms.

This study was conducted with agglutination and hemolysin tests in vitro in which normal and immune horse sera and the erythrocytes of different persons were employed; horse sera were found to contain relatively large amounts of agglutinins for the erythrocytes of some rabbits and were injected intravenously into these animals to determine the effects of agglutination and hemolysis in vivo.

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