1. The relationships in passive anaphylaxis between the sensitizing dose of antibody, the shock dose of antigen and the severity of anaphylactic shock in the guinea pig have been investigated for the ovalbumin, tobacco mosaic virus, SIII and their homologous rabbit antibodies and for the cross reaction between SVIII and anti-SIII.

  2. The sera of guinea pigs sensitized with varying quantities of antibody were assayed for circulating antibody by the micro quantitative precipitin method at the time when shock would usually be elicited.

  3. The significance of differences in the quantitative relationships required for anaphylactic shock in the various antigen-antibody systems and the influence of circulating antibody on the severity of anaphylaxis is discussed.

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Aided by grants from the William J. Matheson Commission and the Commonwealth Fund.

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