The mechanism of the inhibition of isoagglutination in plasma pools was investigated. None of our evidence indicates that the phenomenon is due to a nonspecific factor. It appears that the inhibiting substances are the group-specific agglutinogens. The distribution of these substances among fractions prepared from human plasma was studied.

1

The products of plasma fractionation employed in this work were prepared under contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and Harvard University.

2

This is paper Number 46 in the series, “Studies on Plasma Proteins” from Harvard Medical School, Boston, Massachusetts, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

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