The Antibody Response of Rabbits to a Single Injection of Type I Pneumococci

MacLeod, Colin M.; Heidelberger, Michael; Robinson, Betty; DiLapi, Marie M.; Walter, Annabel W.; Sutliff, Wheelan D.

doi:10.4049/jimmunol.61.2.179

The Antibody Response of Rabbits to a Single Injection of Type I Pneumococci^*

Colin M. MacLeod;

Colin M. MacLeod

(From the

Department of Microbiology, New York University College of Medicine

; the

Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital in the City of New York

, and the

Bureau of Laboratories of the Department of Health of the City of New York)

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Michael Heidelberger;

Michael Heidelberger

(From the

Department of Microbiology, New York University College of Medicine

; the

Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital in the City of New York

, and the

Bureau of Laboratories of the Department of Health of the City of New York)

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Betty Robinson;

Betty Robinson

(From the

Department of Microbiology, New York University College of Medicine

; the

Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital in the City of New York

, and the

Bureau of Laboratories of the Department of Health of the City of New York)

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Marie M. DiLapi;

Marie M. DiLapi

(From the

Department of Microbiology, New York University College of Medicine

; the

Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital in the City of New York

, and the

Bureau of Laboratories of the Department of Health of the City of New York)

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Annabel W. Walter;

Annabel W. Walter

(From the

Department of Microbiology, New York University College of Medicine

; the

Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital in the City of New York

, and the

Bureau of Laboratories of the Department of Health of the City of New York)

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Wheelan D. Sutliff

(From the

Department of Microbiology, New York University College of Medicine

; the

Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital in the City of New York

, and the

Bureau of Laboratories of the Department of Health of the City of New York)

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Received: August 18 1948

Published: February 01 1949

Online Issn: 1550-6606

Print Issn: 0022-1767

Williams & Wilkins Company

J Immunol (1949) 61 (2): 179–183.

https://doi.org/10.4049/jimmunol.61.2.179

Summary

The sera of rabbits subjected to a single antigenic stimulus with Type I pneumococci were analyzed for antibodies to the commonly recognized pneumococcal antigens.
The data are tabulated and are found comparable to similar analyses of sera of human patients recovered from pneumococcal infections and of human subjects injected with small quantities of pneumococci or type-specific pneumococcal polysaccharides.

Footnotes

The work reported in this communication was carried out in part under the Commission on Acute Respiratory Diseases, Army Epidemiological Board, Office of the Surgeon General, United States Army, and in part under the Harkness Research Fund of the Presbyterian Hospital, New York.

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The Antibody Response of Rabbits to a Single Injection of Type I Pneumococci^*

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The Antibody Response of Rabbits to a Single Injection of Type I Pneumococci^*