The administration of a Schistosoma mansoni antigen, prepared from adult worms to mice, before exposing the mice to 10 cercariae each, was associated to a statistically significant degree with a reduction in the number of cercariae which developed into adult worms.

  1. There was no evidence that the antigen had a marked effect, if any, on rate of development; nor that one sex was more susceptible; nor that the localization of the worm was affected.

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