Groups of mice inoculated with 2 to 4 LD 50 doses of Eastern equine, Western equine, St. Louis encephalitis, poliomyelitis or influenza viruses and treated with maximal non-fatal doses of diethyl ether by inhalation, sodium amytal, paraldehyde, avertin, magnesium sulfate, morphine, Cytochrome C, dithiobiuret or dithiocarbamate, prior to and following inoculation with the viruses, showed no alteration in the courses of the ensuing infections.

The theoretical reasons for the use of these compounds in attempts at chemotherapy of virus infections are discussed.

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