Serial specimens of sera obtained during the acute and early convalescent phases of illness from 8 individuals with clinical mumps were studied for the appearance of specific antibodies. The tests employed were complement fixation with soluble and viral antigens, agglutination-inhibition, and agglutination of human erythrocytes modified by treatment with mumps virus (Burnet test). The individual variations were marked. Nevertheless, in 6 of the 8 patients a complement fixing antibody was the first to be detected, and after 2 weeks all of the 8 patients reacted positively in 2 or more of the tests. There was no correlation in titer nor time of appearance of the complement fixing, agglutination-inhibiting nor modified cell agglutinating factors. It is therefore suggested that these represent distinct and independent responses to infection with the virus of mumps.

Addendum. Since this manuscript was submitted for publication a paper on this same subject by Aikawa and Meiklejohn has appeared. (Aikawa, J. K. and Meikeljohn, G., 1949; The serological diagnosis of mumps. A comparative study of three methods. J. Immunol. 62, 261–270.) These authors also found the three tests studied by us to be valid indicators of the presence of antibody to the mumps virus.

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