Guinea pigs injected with crystalline egg albumin in an emulsion with the Freund adjuvants and containing killed tubercle bacilli showed substantially increased and prolonged antibody levels in their serum measured by the quantitative precipitin reaction as compared with guinea pigs injected with a similar emulsion lacking killed tubercle bacilli. The increased antibody formation was correlated with local granuloma formation and hyperplasia in the regional lymph nodes and spleens of animals receiving the emulsion containing killed tubercle bacilli.

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This work was supported by a grant (B-9) from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, U. S. Public Health Service, and in part by the Helen Hay Whitney Foundation, the Masonic Foundation for Medical Research and Human Welfare, and the William J. Matheson Commission.

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