1. Administration of cortisone may shorten or prolong survival of chick embryos infected with influenza B virus, depending on the timing of its injection.

  2. Injection of cortisone 24–42 hours after infection results in suppression of inflammation and prolongation of survival of virus-infected chick embryos.

  3. The ameliorating effects of cortisone in this situation are explicable on the basis of its anti-inflammatory action in the chorioallantoic membrane.

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This investigation was supported in part by a grant from the U.S.P.H.S.

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