1. The persistence for long periods of time of the antibody level to PVP of high molecular weight (1 × 106) in the sera of some of the volunteers has been demonstrated.

  2. Attempts to produce an anamnestic type of response to PVP were not successful. A possible explanation for this behavior was presented.

  3. Inhibition studies with various monomers indicated that the antibody was formed against multiple groupings of N-vinyl pyrrolidone.

  4. Definite differences have been observed in the behavior of different antisera to PVP in the reaction with monomers and stability at 0° and 56°C.

  5. It has been confirmed that long after the disappearance of hemolytic activity nitrogenous materials are present in human sera which can still add to specific precipitates.

1

This investigation was supported by a grant from the Office of the Surgeon General, Department of the Army, Contract No. DA-49-007-MD-248. This is publication No. 115 of the Pathology Department, University of Pittsburgh School of Medicine.

2

Presented in part before the Fortieth Annual Meeting of the American Association of Immunologists, Atlantic City, New Jersey, April, 1956.

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