The formation of precipitates on the addition of γ globulin (Fraction II) to the serum of most patients with rheumatoid arthritis is in general correlated with the FII agglutination titer of the serum.

The quantitative precipitation curve of this reaction is dependent on the FII agglutination titer of the sera, the lot of Fraction II and the volume in which the reaction is performed.

It is likely that the rheumatoid factor and what has been termed the γ globulin factor coexist in serum. A simple precipitation method for the detection of large quantities of rheumatoid factor has been reported.

Supported in part by a research grant (A-1229) from the National Institutes of Health, Arthritis and Metabolic Diseases.

2

Presented in part at the Annual Meeting of the American Rheumatism Association, Chicago, Ill., June, 1956.

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