1. Simons' theory as to the nature of the fundamental reaction in canine anaphylaxis was tested by perfusion methods with isolated tissues.

  2. Distinct vaso-constriction can be demonstrated in the canine lungs by perfusion with a mixture of barium chloride and adrenalin chloride, and marked vaso-constriction by perfusion with ergotin or with Vaughan's protein split-product.

  3. No veno-constriction can be demonstrated in canine livers however by perfusion with any of these agents.

  4. Simons' hepatic veno-constrictor theory, therefore, does not appear to represent a physiologic possibility.

1

Presented before the joint meeting of the American Association of Immunologists and the American Association of Pathologists and Bacteriologists, Washington, D. C., May 2, 1922.

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