Study of the changes in experimental animals brought about by dietary deficiencies has been directed almost exclusively to physiological and anatomical manifestations. The effects which such diets may have upon serological or immunological properties have received but little attention in spite of the fact that there is abundant clinical evidence associating defective diet with decreased resistance. In numerous publications of a clinical nature a direct correlation has been pointed out between a deficient diet and morbidity and mortality rates from inter-current infection. Such findings obviously suggest that under conditions of inadequate nutrition the efficiency of the mechanism of resistance is impaired. In so far as can be determined, the connection between these two conditions has not been submitted to direct experimental proof, either with the clinical material suggesting such a relationship or with experimental animals in which nutritional disturbances were artificially induced.

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