1. The dominant reacting tissues in canine histamine shock are fairly evenly distributed throughout the body.

  2. The most striking reaction in blood-free perfusions of isolated canine tissues is the explosive edema of all organs thus far tested.

  3. Reactions of secondary importance are: (a) Marked decrease in perfusion resistance in the hind quarters, and (b) Marked increase in perfusion resistance in the lungs, liver, intestines and kidneys.

  4. We believe this increased perfusion resistance is largely due to increased tissue pressure from edema.

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