Introduction. One of the outstanding contributions of recent years to the study of the chemistry and physics of the proteins is the demonstration that the reactions of these substances with electrolytes are capable of stoichiometrical analysis. The work of Jacques Loeb and his collaborators, in this country, and of Sorenson and many others has gone far in removing some of these reactions from the fields of more empirical colloid chemistry into the realms of classical chemistry. They have indicated certain important possibilities in the quantitation of the dynamics of systems containing proteins. It is not possible, nor is it desirable, to review this work here. It is perhaps sufficient to refer to the original papers by Loeb and others in the Journal of General Physiology (1918, to date) and to the concise summary in the recent monograph by Loeb (1922) and to the review by Bancroft (1922).

1

The studies reported here were aided by a grant from the Loomis Research Fund of the Yale School of Medicine.

2

Preliminary reports of this work have been presented before the Society of American Bacteriologists (Abstr. Bact., January, 1923) and the Society for Experimental Biology and Medicine, Proceedings for January 17, 1923.

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