In the following series of papers we describe experiments that deal primarily with observations on endothelial permeability as studied by means of lymph analysis. The number of theoretical as well as practical therapeutic problems that are related in an intimate way to alterations of endothelial permeability may justify a study such as this even though we already possess a great amount of information gathered in the laboratories of Ludwig, Heidenhain, Asher, Carlson, Starling and others. Much of the older work was carried out at a time when the knowledge concerning the physico-chemical factors that might modify the permeability of the endothelium had not been developed, while more gross forces, as osmosis, were perhaps over-emphasized. The more recent communications have been quite numerous and in them cognizance has been taken of the modern concepts concerning cellular structure.

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