The fact that anaphylactic shock in the dog is associated with phenomena largely neuroendothelial in character as contrasted to the neuromuscular reaction that predominates in the guinea pig has led to an extensive study of these alterations in the vascular relations. It has been found that the effect on the lymph flow is quite similar to that when lymphagogues of 1st class are injected, i.e., an increased flow of lymph that is more concentrated in solids. This has been ascribed to the increased intraportal pressure. This increase in intraportal pressure has been assumed by some to be due to factors in which the liver is not directly participating, by others, such as Mautner and Pick (1) and Simmonds (2), actual vasoconstriction in the liver is held to be causative. Jaffe (3) has demonstrated smooth muscle fibers about the smaller veins in the liver and states that they are seen most easily when the liver is engorged and the capillary spaces distended.

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